Donor selection and correlation with recipient results
Sánchez Fernando (ES) - GINEMED
Sánchez F, Sánchez P, Estévez M, Hebles M, Migueles B, Dorado M.
Oocyte donation is the only option for a menopausal woman who desires to get pregnant, regardless of ethical considerations, these cases are special so the way to proceed must be different, especially because we mustn’t transfer more than one embryo and we have to get pregnant quickly. Plus the normal way of donor selection (phenotypic, infectious, genetic, familiar…) we must take care of some other items like donor age or previous results. We did a retrospective analysis of 674 cycles of egg donation (2008-10), excluding the severe male factor. There are no differences in pregnancy rate (PR) when the donor is under 30. If we look at the results of the current cycle in the light of the previous one we found: first cycle, PR 56.7 %, n 180; pregnancy in a previous cycle, PR 63.9%, n 420; no pregnancy in previous cycle, PR 48.5%, n 74, p< 0,05. There are no differences when we evaluate the stimulation protocol, days, doses or drugs used. We found a statistical correlation between the number of donated MII eggs and the results (<8 eggs, n 246, PR 54.31; >8 eggs, n 428, PR 63.73, p <0,05) This difference is more important if we add the results of one frozen cycle in patients who didn’t get pregnant in the fresh transfer (< 8 eggs, PR 67.4 %; > 8 eggs, PR 84.6 %, p < 0.05). There are no differences in terms of PR regarding to the recipient's age, even over 50, or the cycle indication (premature menopause, natural menopause, premenopause, genetic, surgery, quimiotherapy, multiple failure in IVF cycles or others). Based on these results, for menopause women we strongly recommend the Single Embryo Transfer, if it’s possible in blastocyst stage, of an embryo which came form a probated young donor less than 30 years old who gives at least 8 MII, and vitrify the rest of the embryos for a second chance.
--------------------------------------------------------------------------------
No hay comentarios:
Publicar un comentario